WP6 – Functional validation of regulatory variants

WP6 Functional validation of regulatory variants WP Leader: Hiroaki Taniguchi (IGHZ PAN) IGHZ PAN, FBN, INRAE, UNILIM
Task 6.1 Annotation of candidate causative regulatory variants Task Leader: Maria Bernard (INRAE) INRAE
Task 6.2 Reporter gene screen for candidate regulatory variant validation Task Leader: Dominique Rocha (INRAE) INRAE
Task 6.3 Cell-based in vitro validation of functional variants Task Leader: Veronique Blanquet (UNILIM) UNILIM, FBN, IGHZ PAN
Task 6.4 Validation of promoter/enhancer interactions Task Leader: Hiroaki Taniguchi (IGHZ PAN) IGHZ PAN, INRAE

 

WP6 objectives

WP6 will functionally validate (i) key candidate regulatory sequences and (ii) variants associated with disease resistance, biological efficiency and robustness, identified in WP2 and WP4, respectively. Regulatory element interactions and the relation between selected candidate variants will be assessed with different environmental stressor(s). Results from WP6 will help prioritize the genetic variants used in bd-GP tools (WP7).